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KMID : 1035620140020030218
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Allergy Asthma & Respiratory Disease
2014 Volume.2 No. 3 p.218 ~ p.221
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Successful desensitization of trimethoprim-sulfamethoxazole in Stenostrophomonas maltophilia osteomyelitis
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Kim Soo-Jung
Lim Kyung-Hwan
Kang Min-Gyu
Park Han-Ki
Cho Sang-Heon
Min Kyung-Up
Kim Sae-Hoon
Chang Yoon-Seok
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Abstract
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Stenotrophomonas maltophilia is an emerging pathogen associated with morbidity and mortality in hospitalized patients. The treatment of S. maltophilia infection is challenging because clinical isolates are frequently resistant to most antimicrobial agents except trimethoprim-sulfamethoxazole (TMP-SMX). S. maltophilia osteomyelitis is a rare disease and requires a prolonged treatment with TMP-SMX. Here, we report an interesting case of a patient with S. maltophilia osteomyelitis who developed a delayed hypersensitivity reaction during TMP-SMX treatment and successfully treated after desensitization. TMP-SMX desensitization should be considered in patients with hypersensitivity to TMP-SMX, especially when there are no effective alternative drugs in S. maltophilia infection.
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KEYWORD
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Immunologic desensitization, Hypersensitivity, Trimethoprim-sulfamethoxazole combination, Stenotrophomonas maltophilia
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